C1-set domains are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.

Human proteins containing this domain

AZGP1 Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the ''AZGP1'' gene. This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mouse, mice, is associated with the cachexia related to ca ...

; B2M;

CD1A #REDIRECT CD1A {{R from different capitalization ...

;

CD1B T-cell surface glycoprotein CD1b is a protein that in humans is encoded by the CD1B gene. CD1b belongs to group 1 of CD1 family of transmembrane glycoproteins. CD1 molecules are expressed on the surface of numerous different human antigen presen ...

; CD1C;

CD1D CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to ...

;

CD1E T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the ''CD1E'' gene. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompa ...

; DMA; DQB2; DRB1; ELK2P1;

FCGRT The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Francis Brambell, Brambell receptor) is a protein that in humans is encoded by the ''FCGRT'' gene. It is an Fc receptor, IgG Fc receptor which is similar in structure to ...

; HFE; HHLA2;

HLA-A HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of ...

;

HLA-B HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) compl ...

;

HLA-B35 HLA-B35 (B35) is an HLA- B serotype A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on t ...

; HLA-B57;

HLA-C HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA ...

; HLA-CW; HLA-Cw;

HLA-D The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for the regulation of the immune system. The HLA system is also known as the human version of th ...

;

HLA-DMA HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the ''HLA-DMA'' gene. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA ...

;

HLA-DMB HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the ''HLA-DMB'' gene. Function HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an ...

;

HLA-DOA HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the ''HLA-DOA'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredit ...

;

HLA-DOB HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the ''HLA-DOB'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredit ...

;

HLA-DP HLA-DP is a protein/peptide-antigen receptor and graft-versus-host disease antigen that is composed of 2 subunits, DPα and DPβ. DPα and DPβ are encoded by two loci, HLA-DPA1 and HLA-DPB1, that are found in the MHC Class II (or HLA-D) region i ...

;

HLA-DPA1 Major histocompatibility complex, class II, DP alpha 1, also known as HLA-DPA1, is a human gene. Function The protein encoded by this gene belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting o ...

;

HLA-DPB1 HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the ''HLA-DPB1'' gene. HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha ( ...

;

HLA-DQA1 Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of tw ...

;

HLA-DQA2 HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the ''HLA-DQA2'' gene. Also known as ''HLA-DXA'' or ''DAAP-381D23.2'', it is part of the human leucocyte antigen system. The protein encoded by t ...

; HLA-DQB1; HLA-DQB2;

HLA-DRA HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is pra ...

;

HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the ''HLA-DRB1'' gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at ...

; HLA-DRB2;

HLA-DRB3 HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the ''HLA-DRB3'' gene. Function The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is ...

;

HLA-DRB4 Major histocompatibility complex, class II, DR beta 4, also known as HLA-DRB4, is a human gene. Function The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an ...

; HLA-DRw12; HLA-Dw12;

HLA-E HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the ''HLA-E'' gene. The human HLA-E is a non-classical MHC class I molecule that is characterized by a limit ...

;

HLA-F HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the ''HLA-F'' gene. It is an empty intracellular molecule that encodes a non-classical heavy chain anchored to the membrane and forming a heterodimer w ...

;

HLA-G HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the ''HLA-G'' gene. HLA-G belongs to the HLA nonclassical class I heavy chain paralogues. Classical HLA I pro ...

; HLA-G2.2; HLA-H; HLAC; IGHA1; IGHA2;

IGHD Ig delta chain C region is a protein that in humans is encoded by the ''IGHD'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

;

IGHE Ig epsilon chain C region is a protein that in humans is encoded by the ''IGHE'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

;

IGHG1 Ig gamma-1 chain C region is a protein that in humans is encoded by the ''IGHG1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

;

IGHG2 Ig gamma-2 chain C region is a protein that in humans is encoded by the ''IGHG2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

;

IGHG3 Ig gamma-3 chain C region is a protein that in humans is encoded by the ''IGHG3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' o ...

;

IGHG4 Ig gamma-4 chain C region is a protein that in humans is encoded by the ''IGHG4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

;

IGHM Ig mu chain C region is a protein that in humans is encoded by the ''IGHM'' gene. It is associated with agammaglobulinemia Hypogammaglobulinemia is a problem with the immune system in which not enough gamma globulins are produced in the blood ...

; IGHV4-31;

IGKC Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies. It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@ Immunoglobulin ka ...

; IGKV1-5; IGKV2-24;

IGL@ Immunoglobulin lambda locus, also known as IGL@, is a region on the q arm of human chromosome 22, region 11.22 (22q11.22) that contains genes for the lambda light chains of antibodies (or immunoglobulins). Function Immunoglobulins recognize ...

; IGLC1; IGLC3;

IGLL1 Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the ''IGLL1'' gene. IGLL1 has also recently been designated CD179B (cluster of differentiation 179B). It is associated with agammaglobulinemia Hypogammaglobulin ...

; IGLV2-14; IGLV3-21; IGLV3-25; IGLV4-3;

MICA Micas ( ) are a group of silicate minerals whose outstanding physical characteristic is that individual mica crystals can easily be split into extremely thin elastic plates. This characteristic is described as perfect basal cleavage. Mica is ...

; MICB; MR1;

SIRPA Sirpa is a village development committee in Rolpa District in the Rapti Zone of north-eastern Nepal. At the time of the 1991 Nepal census The 1991 Nepal census was a widespread national census conducted by the Nepal Central Bureau of Statisti ...

;

SIRPB1 Signal-regulatory protein beta-1 is a protein that in humans is encoded by the ''SIRPB1'' gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B). The protein encoded by this gene is a member of the signal-regulator ...

;

SIRPG Signal-regulatory protein gamma is a protein that in humans is encoded by the ''SIRPG'' gene. SIRPG has also recently been designated CD172G (cluster of differentiation 172G). The protein encoded by this gene is a member of the signal-regulatory ...

; SNC73; TAPBP; TAPBPL; TRBC1; TRBV19; TRBV21-1; TRBV3-1; TRBV5-4; TRBV7-2; micB;

References

Protein domains Single-pass transmembrane proteins {{InterPro content, IPR003597